Penicillin g benzathine
Bicillin (penicillin g benzathine) is a small molecule pharmaceutical. Penicillin g benzathine was first approved as Permapen on 1982-01-01. It is used to treat actinomycosis, anthrax, bacterial infections, bacterial skin diseases, and botulism amongst others in the USA.
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Bicillin l-a (discontinued: Bicillin, Bicillin l-a, Permapen)
CombinationsBicillin c-r (discontinued: Bicillin c-r)
Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Penicillin g benzathine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| BICILLIN L-A | King Pharmaceuticals | N-050141 RX | 1982-01-01 | 1 products, RLD, RS |
Show 5 discontinued
Penicillin g benzathine
+
Penicillin g procaine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| BICILLIN C-R | King Pharmaceuticals | N-050138 RX | 1982-01-01 | 1 products, RLD, RS |
| BICILLIN C-R 900/300 | King Pharmaceuticals | N-050138 RX | 1982-01-01 | 1 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| bicillin c-r 900/300 | New Drug Application | 2024-06-03 |
| bicillin cr | New Drug Application | 2024-06-04 |
| bicillin l-a | New Drug Application | 2024-07-12 |
| extencilline | unapproved drug for use in drug shortage | 2024-07-18 |
| lentocilin | unapproved drug for use in drug shortage | 2024-06-07 |
| neolinn | OTC monograph not final | 2021-06-02 |
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Agency Specific
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Clinical
Clinical Trials
71 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Syphilis | D013587 | EFO_0007504 | A53.9 | 1 | 3 | 5 | 6 | 3 | 17 |
| Pneumonia | D011014 | EFO_0003106 | — | — | 1 | 3 | 1 | 2 | 6 |
| Infections | D007239 | EFO_0000544 | — | — | 1 | 2 | 1 | 1 | 5 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | 1 | 2 | 1 | 1 | 4 |
| Hypersensitivity | D006967 | HP_0012393 | T78.40 | — | 1 | — | 1 | 2 | 4 |
| Yaws | D015001 | EFO_0007548 | A66 | — | — | 2 | 1 | — | 3 |
| Communicable diseases | D003141 | — | — | — | — | 1 | 1 | 1 | 3 |
| Drug hypersensitivity | D004342 | EFO_0009482 | T88.7 | — | 1 | — | 1 | 1 | 3 |
| Respiratory tract infections | D012141 | — | J06.9 | — | — | — | 1 | 1 | 2 |
| Bacteremia | D016470 | EFO_0003033 | R78.81 | — | — | — | 2 | — | 2 |
Show 8 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sepsis | D018805 | HP_0100806 | A41.9 | — | — | 2 | — | 2 | 4 |
| Neurosyphilis | D009494 | EFO_0007339 | A50.4 | — | — | 1 | — | 2 | 3 |
| Treponemal infections | D014211 | EFO_1001217 | — | — | — | 2 | — | — | 2 |
| Bacterial infections | D001424 | — | A49 | — | — | 1 | — | 1 | 2 |
| Neonatal sepsis | D000071074 | HP_0040187 | — | — | — | 1 | — | 1 | 2 |
| Toxemia | D014115 | — | — | — | — | 1 | — | 1 | 2 |
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | — | 1 | 1 | — | — | 1 |
| Cytomegalovirus infections | D003586 | EFO_0001062 | B25 | — | 1 | 1 | — | — | 1 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | — | 1 | — | — | 1 |
| Microbial drug resistance | D004352 | — | — | — | — | 1 | — | — | 1 |
Show 10 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | 2 | — | — | 2 | 4 |
| Rheumatic heart disease | D012214 | EFO_1001161 | I09.9 | — | 2 | — | — | 2 | 4 |
| Rheumatic diseases | D012216 | — | M79.0 | — | 2 | — | — | 1 | 3 |
| Urinary bladder neoplasms | D001749 | — | C67 | 2 | 1 | — | — | — | 3 |
| Non-muscle invasive bladder neoplasms | D000093284 | — | — | 2 | 1 | — | — | — | 3 |
| Psoriasis | D011565 | EFO_0000676 | L40 | — | 1 | — | — | 1 | 2 |
| Covid-19 | D000086382 | — | — | — | 1 | — | — | — | 1 |
| Congenital abnormalities | D000013 | EFO_0003915 | Q89.9 | — | 1 | — | — | — | 1 |
| Lymphangioma | D008202 | — | D18.1 | — | 1 | — | — | — | 1 |
| Lymphatic abnormalities | D044148 | — | — | — | 1 | — | — | — | 1 |
Show 2 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
| Streptococcal infections | D013290 | EFO_1001476 | — | 1 | — | — | — | 1 | 2 |
| Pharyngitis | D010612 | — | R07.0 | 1 | — | — | — | 1 | 2 |
| Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | — | — | — | — | 1 |
| Bacterial vaginosis | D016585 | EFO_0003932 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Critical illness | D016638 | — | — | — | — | — | — | 1 | 1 |
| Hiv seropositivity | D006679 | — | — | — | — | — | — | 1 | 1 |
| Hepatitis c | D006526 | — | B19.2 | — | — | — | — | 1 | 1 |
| Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | — | — | — | — | 1 | 1 |
| Hepatitis | D006505 | HP_0012115 | K75.9 | — | — | — | — | 1 | 1 |
| Hepatitis a | D006506 | EFO_0007305 | B15 | — | — | — | — | 1 | 1 |
| Psoriatic arthritis | D015535 | EFO_0003778 | L40.5 | — | — | — | — | 1 | 1 |
| Ulcerative colitis | D003093 | EFO_0000729 | K51 | — | — | — | — | 1 | 1 |
| Ankylosing spondylitis | D013167 | EFO_0003898 | M45 | — | — | — | — | 1 | 1 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | — | — | 1 | 1 |
Show 13 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Penicillin g benzathine |
| INN | — |
| Description | Benzathine benzylpenicillin, also known as benzathine penicillin G, is an antibiotic medication useful for the treatment of a number of bacterial infections. Specifically it is used to treat strep throat, diphtheria, syphilis, and yaws. It is also used to prevent rheumatic fever. It is given by injection into a muscle.
|
| Classification | Small molecule |
| Drug class | penicillins |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)O.CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)O.O.O.O.O.c1ccc(CNCCNCc2ccccc2)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 1538-09-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3989515 |
| ChEBI ID | — |
| PubChem CID | 15232 |
| DrugBank | DB09323 |
| UNII ID | — |
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Bicillin – Pfizer
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Penicillin g benzathine
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Trends
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Safety
Black-box Warning
Black-box warning for: Bicillin c-r 900/300, Bicillin cr, Bicillin l-a
Adverse Events
Top Adverse Reactions
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1,080 adverse events reported
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