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Drug ReportsPenicillin g benzathine
Penicillin g benzathine
Bicillin (penicillin g benzathine) is a small molecule pharmaceutical. Penicillin g benzathine was first approved as Permapen on 1982-01-01. It is used to treat actinomycosis, anthrax, bacterial infections, bacterial skin diseases, and botulism amongst others in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
musculoskeletal diseasesD009140
respiratory tract diseasesD012140
nervous system diseasesD009422
urogenital diseasesD000091642
cardiovascular diseasesD002318
skin and connective tissue diseasesD017437
animal diseasesD000820
signs and symptoms pathological conditionsD013568
chemically-induced disordersD064419
Trade Name
FDA
EMA
Bicillin l-a (discontinued: Bicillin, Bicillin l-a, Permapen)
Combinations
Bicillin c-r (discontinued: Bicillin c-r)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Penicillin g benzathine
Tradename
Company
Number
Date
Products
BICILLIN L-AKing PharmaceuticalsN-050141 RX1982-01-01
1 products, RLD, RS
Show 5 discontinued
Penicillin g benzathine
+
Penicillin g procaine
Tradename
Company
Number
Date
Products
BICILLIN C-RKing PharmaceuticalsN-050138 RX1982-01-01
1 products, RLD, RS
BICILLIN C-R 900/300King PharmaceuticalsN-050138 RX1982-01-01
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
bicillin c-r 900/300New Drug Application2024-06-03
bicillin crNew Drug Application2024-06-04
bicillin l-aNew Drug Application2024-07-12
extencillineunapproved drug for use in drug shortage2024-07-18
lentocilinunapproved drug for use in drug shortage2024-06-07
neolinnOTC monograph not final2021-06-02
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
respiratory tract infections—D012141J06.9
pericarditisEFO_0007427D010493I30
urinary tract infectionsEFO_0003103D014552N39.0
pneumococcal infectionsEFO_0000772D011008J13
bacterial infections—D001424A49
gonorrheaDOID_7551D006069A54
bacterial skin diseases—D017192—
escherichia coli infectionsEFO_1001318D004927B96.20
syphilisEFO_0007504D013587A53.9
staphylococcal infections—D013203A49.01
Show 15 more
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01C: Beta-lactam antibacterials, penicillins
— J01CE: Beta-lactamase sensitive penicillins
— J01CE08: Benzathine benzylpenicillin
HCPCS
Code
Description
J0558
Injection, penicillin g benzathine and penicillin g procaine, 100,000 units
J0561
Injection, penicillin g benzathine, 100,000 units
Clinical
Clinical Trials
837 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———4————4
MalnutritionD044342EFO_0008572E40-E461————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePenicillin g benzathine
INN—
Description
Benzathine benzylpenicillin, also known as benzathine penicillin G, is an antibiotic medication useful for the treatment of a number of bacterial infections. Specifically it is used to treat strep throat, diphtheria, syphilis, and yaws. It is also used to prevent rheumatic fever. It is given by injection into a muscle.
Classification
Small molecule
Drug classpenicillins
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Structure (InChI/SMILES or Protein Sequence)
CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)O.CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)O.O.O.O.O.c1ccc(CNCCNCc2ccccc2)cc1
Identifiers
PDB—
CAS-ID1538-09-6
RxCUI—
ChEMBL IDCHEMBL3989515
ChEBI ID—
PubChem CID15232
DrugBankDB09323
UNII ID—
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Bicillin – Pfizer
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Estimated US medical usage
Penicillin g benzathine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 4,795 documents
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Safety
Black-box Warning
Black-box warning for: Bicillin c-r 900/300, Bicillin cr, Bicillin l-a
Adverse Events
Top Adverse Reactions
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1,184 adverse events reported
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